Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction
نویسندگان
چکیده
منابع مشابه
Study of the Mechanism and Causes of Pore Formation in Sr-modified Al-Si Alloys
The formation of microporosity in modified Al-Si alloys has been reviewed in the present study. A major concern in modification is the increased tendency to form microporosity in the macro-shrinkage free Al-Si alloy castings. It has also been demonstrated that at low hydrogen contents (0.1cc/ 100g, Al), where only shrinkage porosity should occur, the effect of Sr-modification on porosity conten...
متن کاملStudy of the Mechanism and Causes of Pore Formation in Sr-modified Al-Si Alloys
The formation of microporosity in modified Al-Si alloys has been reviewed in the present study. A major concern in modification is the increased tendency to form microporosity in the macro-shrinkage free Al-Si alloy castings. It has also been demonstrated that at low hydrogen contents (0.1cc/ 100g, Al), where only shrinkage porosity should occur, the effect of Sr-modification on porosity conten...
متن کاملPore Formation Mechanism of Staphylococcal Pore- forming Toxin
Y. Tanaka and M. Yao (Hokkaido Univ.) Pathogenic bacteria express pore-forming toxins (PFTs) to attack host cells. PFTs are expressed as soluble monomeric proteins, which assemble to prepore oligomer on the target cells. After forming prepore, conformational change occurs, and then the pore is formed. Although the crystal structures of monomer and pore have been determined, the detailed mechani...
متن کاملMolecular mechanism of pore formation by actinoporins.
Actinoporins are effective pore-forming toxins produced by sea anemones. These extremely potent, basic 20 kDa proteins readily form pores in membranes that contain sphingomyelin. Much has been learned about the molecular basis of their pore-forming mechanism in recent years. Pore formation is a multi-step process that involves recognition of membrane sphingomyelin, firm binding to the membrane ...
متن کاملMultivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity
Aggregates of amyloid-beta (Aβ) peptides are thought to be involved in the development of Alzheimer's disease because they can change synaptic plasticity and induce neuronal cell death by inflammation, oxidative damage, and transmembrane pore formation. Exactly which oligomeric species underlie these cytotoxic effects remains unclear. The work presented here established well-controlled aggregat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.04.026